Journal: Regenerative Therapy

Article Title: Engineering cardiac regeneration using stem cells: Cellular sources, differentiation signatures, targeted delivery, and functional recovery

doi: 10.1016/j.reth.2026.101120

Figure Lengend Snippet: Pluripotency and differentiating capacity of embryonic stem cells (ESCs). ESCs are created from the inner cell mass (ICM) of the blastocyst stage. They can develop into all three germ layers: the ectoderm (which later gives rise to the brain, skin, and eyes), the endoderm (which gives rise to the lungs, liver, and gut), and the mesoderm (which gives rise to the bones, blood, and muscles). ESCs undergo in vitro differentiation using specific protocols, forming embryoid bodies that mimic early-stage embryogenesis. They may also be implanted in vivo, where they can assist in tissue regeneration. Still, they may, in rare cases, develop into teratomas: complex tumors that contain tissues from all three germ layers. ESCs may also assist in repairing organs, although they may be unregulated and pose risks such as teratocarcinoma.

Article Snippet: Embryonic Stem Cells (ESCs) , - Regeneration of damaged myocardium - replacement of cardiomyocytes , Differentiation into functional cardiomyocytes , Geron Corporation studies (preclinical models) [ ] .

Techniques: Muscles, In Vitro, In Vivo

Journal: Materials Today Bio

Article Title: Targeted antibacterial and mesenchymal stem cell-modulatory hydrogel for periodontitis treatment

doi: 10.1016/j.mtbio.2026.103043

Figure Lengend Snippet: Schematic diagram of the ACP@Z@C hydrogel for periodontitis treatment. The BA-modified CC hydrogel for the delivery of CAPE-loading MOF, which accomplishes the targeted and controlled release of ZIF-8@CAPE in oral microenvironment. The released ZIF-8@CAPE interferes with multiple periodontitis-driven factors, including anti-bacteria, ROS-scavenging, and anti-inflammation. These potency transforms into periodontal tissue regeneration via rescuing the impaired osteogenic differentiation of MSCs.

Article Snippet: Rat bone marrow mesenchymal stem cells (MSCs) was purchased from Procell (Wuhan, China).

Techniques: Modification, Bacteria

Journal: Materials Today Bio

Article Title: Targeted antibacterial and mesenchymal stem cell-modulatory hydrogel for periodontitis treatment

doi: 10.1016/j.mtbio.2026.103043

Figure Lengend Snippet: Inhibiting inflammatory factor by adjusting mitochondrial dysfunction via SIRT1/p-AMPK/PGC-1α pathway. (A) Schematic illustration of the molecular mechanism by which Z@C regulates mitochondrial dysfunction and suppresses inflammatory factor production in MSCs. (B) Representative western blot bands and quantitative analysis of (C) SIRT1, (D) p-AMPK, (E) PGC-1α, (F) NLRP3, and (G) Pro-Caspase-1 protein expression. Data were presented as mean ± SD, n = 3, ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001. Expression levels of (H) SIRT1, (I) PGC-1α, (J) NLRP3, (K) IL-1β, (L) IL-6, and (M) TNF-α following Z@C treatment. Data were presented as mean ± SD, n = 5, ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001. (N) Immunofluorescence staining of SIRT1 expression in MSCs following different groups and (O) quantitative analysis. Data were presented as mean ± SD, n = 3, ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001.

Article Snippet: Rat bone marrow mesenchymal stem cells (MSCs) was purchased from Procell (Wuhan, China).

Techniques: Western Blot, Expressing, Immunofluorescence, Staining